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KMID : 1145520150010020075
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Journal of Radiopharmaceuticals and Molecular Probes
2015 Volume.1 No. 2 p.75 ~ p.79
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Re-evaluation of [18F]fluorobenzaldehyde as a prosthetic group
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Choe Yearn-Seong
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Abstract
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[18F]Fluorobenzaldehyde, which is a versatile radioactive prosthetic group, can undergo reduction, reductive amination, or oxidation to be used for synthesis of diverse radiotracers. This review covers synthesis of [18F]fluorobenzaldehyde and its conversion to secondary prosthetic groups, and also highlights its application to the development of radiotracers.
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KEYWORD
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[18F]Fluorobenzaldehyde, Trimethylammoniumbenzaldehyde triflate, Iodonium salt, Prosthetic group, Reduction, Reductive amination (alkylation), Oxidation
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